Correlation between atazanavir and hyperbilirubinemia

Hyperbilirubinemia is a common and reversible adverse event with atazanavir (ATV). Polymorphism at the uridin-glucoronosyl-transferse 1A1 (UGT1A1) and multidrug resistance 1 (MDR1) genes may influence bilirubin and ATV plasma concentrations respectively. A linear correlation between ATV plasma concentrations (Ctrough) and bilirubin has not been shown but severe hyperbilirubinemia is more frequent with higher ATV plasma levels. As shown in our case report, therapeutic drug monitoring is useful to evaluate ATV Ctrough variability in clinical practice. However, atazanavir remains a manageable and tolerable drug.
Keywords: Atazanavir; Hyperbilirubinemia; Therapeutic drug monitoring; HIV.

Articolo presente in – HAART and correlated pathologies n. 1

Download del’articolo download_pdf

golden goose outlet online golden goose femme pas cher fjallraven kanken backpack sale fjallraven kanken rugzak kopen fjällräven kånken reppu netistä fjallraven kanken táska Golden Goose Tenisice Hrvatska Basket Golden Goose Homme Golden Goose Sneakers Online Bestellen Kanken Backpack On Sale Fjallraven Kanken Mini Rugzak Fjällräven Kånken Mini Reppu Fjallraven Kanken Hátizsák nike air max 270 schuhe neue nike air schuhe nike schuhe damen 2019